The best Side of rheumatoid arthritis meaning

A growing number of people across the globe are suffering as their immune systems cannot longer tell the difference between healthy cells and invading micro-organisms. Instead of protecting themselves from illness the organs and tissues are being attacked by the same defenses.




International research efforts are underway to stop this trend. An initiative based in London known as the Francis Crick Institute, has two world-renowned experts. James Lee & Carola Vinuesa created separate research teams to figure the causes behind autoimmune disease.


Numbers of autoimmune cases started to rise around 40 years ago in the west, Lee told the Observer. However, these illnesses are now showing up in nations that haven't seen them before.


For instance, the largest recent increase in cases of inflammatory bowel disease has occurred located in the Middle East and east Asia. Before this, people had barely ever heard of the disease.


Type 1 diabetes is often associated with rheumatoid or multiple sclerosis. In all cases your immune system gets confused and switches to healthy tissue over infectious agents.


The UK is home to at least 4,000,000 people who have these conditions. There are also many other. In the world, it's thought that the number of autoimmune disorders is increasing at the rate of 3%-9% per annum. Many scientists believe that environmental factors play a major role in this rise.


Lee who worked previously at Cambridge University, said that the human genetic makeup hasn't changed in the past decades. There must be something outside that's responsible for our predisposition to autoimmune disease.


Vinuesa was the one who was the one who believed in this concept. Vinuesa was previously at the Australian National University. She pointed out that changes in diet were taking place when more nations adopted Western-style diets and more people were buying fast food.


Vinuesa indicated that the lack of some vital ingredients in fast-food meals can result in a decrease in the intake of essential nutrients, like fiber.


These changes in microbiomes lead to autoimmune disorders. There are over 100 different types.


Both scientists stressed that individual vulnerability was a factor in the development of diseases like these, which also comprise celiac diseases as well as lupus, which triggers inflammation and swelling and can cause harm to different organs, such as the heart.


Vinuesa claims that anyone who does not have a particular genetic susceptibility to develop an autoimmune disorder regardless of how many Big Macs they eat. We can't stop the growth of fast-food outlets all over the world. Instead, our focus is in understanding the genetic mechanisms that cause autoimmune diseases and the reasons why certain people are more susceptible than others not. This is the stage that we are aiming to address this issue."


Scientists have the capability to identify tiny differences in DNA between large numbers of people. This is possible because of the advancement of technology. It is possible to identify common genetic patterns among individuals who suffer from an autoimmune disease.


Lee says that although we had tools for sequencing DNA up to the point of being able to sequence DNA, until recent, it was not possible. My research showed that there were around six DNA variations that are involved in the trigger of inflammatory bowel disease. We now have more than 250.


Lee and Vinuesa are pursuing these kinds of research because they want to understand how genetic pathways work and the causes of the various diseases that doctors are currently studying. Vinuesa explained that there may be multiple Read More variants of diseases that are autoimmune, such as Lupus. It is crucial to recognize the implications of this when trying to determine the correct treatment.


Although there are many potentially effective new therapies in development but we aren't sure the patients they should be administered to. This is due to the fact that we do not know the exact type of their illness. That's the main goal of the research into autoimmune diseases. To determine the most effective treatment, it is necessary to be able to categorize and categorize patients.


Lee said that with the rising incidence of autoimmune diseases across the world, new therapies and medicines are required more urgently than ever before. There are currently no cures for autoimmune illnesses, which usually develop at a young age - as they are trying to complete their studies, secure their first job, and start families, he said.


This means Read More that more patients will require regular injections for the remainder of their lives. This can be extremely stressful for patients, and also a huge strain on the health services. We require new and efficient treatments.


Rheumatoid arthritis is an auto-immune condition, which means it's due to the immune system attacking healthy tissue in the body. We don't know what triggers it.


Your immune system normally produces antibodies that fight bacteria and viruses in order to fight off infection.


If you have Rheumatoid Arthritis, your immune system is sending antibodies to the joint's lining and attack the tissues surrounding the joint.


The thin layer of cells (synovium), that covers your joints, gets inflamed and painful.


bones

cartilage - the stretchy connective tissue between bones

Tendons connect bone to muscles

Ligaments The ligaments are the tissues that connects bones and cartilage.

If the problem isn't treated, it could result in the loss of alignment and shape. It can eventually destroy the joint.


There are many theories about the reasons why your immune system attacks joints, such as the possibility of an infection as an trigger. But none of these theories has been proven to be true.

Possible risk factors

There are many factors which can increase your risk of developing rheumatoid arthritis including:


Your genes - There is some evidence that rheumatoid arthritis can be passed through families. However, the probability of it being passed on to children is low as genes play an insignificant influence on the condition.

Hormones The autoimmune disease Rheumatoid is more prevalent than ever among women, perhaps because of the hormonal effects of oestrogen. This link, however, has never been proven.

Smoking is a risk factor - Research suggests that those who smoke are more likely develop rheumatoidarthritis.